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A process chain for measuring and analyzing freeform optics is developed for the OptiPro UltraSurf 5x 400 optical coordinate measuring machine. A test case of molded BD6 Alvarez lenses demonstrates measurement repeatability and reproducibility. 

A novel Vision ray metrology technique is reported that estimates the geometric wavefront of a measurement sample using the sample-induced deflection in the vision rays. Vision ray techniques are known in the vision community to provide image formation models even when conventional camera calibration techniques fail. This work extends the use of vision rays to the area of optical metrology. In contrast to phase measuring deflectometry, this work relies on differential measurements, and hence, the absolute position and orientation between target and camera do not need to be known. This optical configuration significantly reduces the complexity of the reconstruction algorithms. The proposed vision ray metrology system does not require mathematical optimization algorithms for calibration and reconstruction – the vision rays are obtained using a simple 3D fitting of a line. 

Naked mole-rats are extraordinarily long-lived rodents that offer unique opportunities to study the molecular origins of age-related neurodegenerative diseases. Remarkably, they do not accumulate amyloid plaques, even though their brains contain high concentrations of amyloid beta (Aβ) peptide from a young age. Therefore, they represent a particularly favourable organism to study the mechanisms of resistance against Aβ neurotoxicity. Here we examine the composition, phase behaviour, and Aβ interactions of naked mole-rat brain lipids. Relative to mouse, naked mole-rat brain lipids are rich in cholesterol and contain sphingomyelin in lower amounts and of shorter chain lengths. Proteins associated with the metabolism of ceramides, sphingomyelins and sphingosine-1-phosphate receptor 1 were also found to be decreased in naked mole-rat brain lysates. Correspondingly, we find that naked mole-rat brain lipid membranes exhibit a high degree of phase separation, with the liquid ordered phase extending to 80% of the supported lipid bilayer. These observations are consistent with the ‘membrane pacemaker’ hypothesis of ageing, according to which long-living species have lipid membranes particularly resistant to oxidative damage. We also found that exposure to Aβ disrupts naked mole-rat brain lipid membranes significantly, breaking the membrane into pieces while mouse brain derived lipids remain largely intact upon Aβ exposure. 

Precision glass molding is a viable process for the cost-effective volume production of freeform optics. Process development is complex, requiring iterative trials of mold manufacture and metrology, glass mold prototyping, metrology and functional testing. This paper describes the first iteration in the development of a process for an Alvarez lens for visible light. The challenges of this optic are extremely tight band-RMS tolerances on a freeform shape over a maximum clear aperture of 45 mm, a 16:1 aspect ratio and a freeform departure of 329 micrometers. A freeform glass mold for an Alvarez lens was manufactured by coordinated-axis diamond turning in a mold substrate using a custom tool error correction method. The results of prototype precision glass molding are also reported. Mold surfaces and molded optical surfaces are analyzed with scanning white light interferometry. A surface roughness of approximately 3 nm RMS is obtained for both the mold substrate and the glass optic with high-fidelity reproduction of micro-surface structure in the glass. These measurements also identify challenging areas, particularly the presence of mid-spatial frequency errors on the optic originating from the machine thermal control system. The form of the molds was also measured with a profilometer; however, the mold surface does not agree with the expected prescription with an overall deviation in form of approximately 10 μm. The machining process is expected to have sub-micrometer error and the sources of this discrepancy are still being determined. Metrology of the glass optics is currently in progress.